https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22365 Wed 11 Apr 2018 15:33:32 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8305 Sat 24 Mar 2018 08:40:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1803 Sat 24 Mar 2018 08:27:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26418 Sat 24 Mar 2018 07:27:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33872 Pseudokirchneriella subcapitata and Chlorella sp. MM3. The toxicity criteria included were: chlorophyll a content as a growth parameter and induction of enzyme activities linked to oxidative stress. Increase in concentrations of diesel or its WAF significantly increased toxicity towards growth, measured in terms of chlorophyll a content in both the algae. Activities of antioxidant enzymes such as superoxide dismutase (SOD), peroxidase (POX) and catalase (CAT) in response to addition of diesel or diesel WAF to the microalgal cultures were dose-dependent. Diesel WAF was more toxic than diesel itself, suggesting that use of WAF may be more relevant for environmental risk assessment of diesel. The overall response of the antioxidant enzymes to toxicants’ stress followed the order: POX≥SOD>CAT. The present study clearly demonstrated the use of SOD, POX and CAT as suitable biomarkers for assessing diesel pollution in aquatic ecosystem.]]> Mon 21 Jan 2019 10:42:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34032 Dracocephalum moldavica L. (DML), a Chinese herbal medicine is known to exert protective effects on myocardial ischemia reperfusion injury in rats by inhibiting oxidation damage and inflammatory reactions. However, the effectiveness of DML in cerebral ischemia reperfusion injury (CIRI) as a protective substance and the underlying mechanisms remain to be determined. The aim of this study was thus to examine the influence of DML on CIRI using a rat model induced by 2-h transient middle cerebral artery occlusion (MCAO) produced by intraluminal suture blockade followed by 22 h reperfusion. The parameters determined include neurological behavior, histochemical assessment of cerebral infarct volume, and determination of various metabolic biomarkers. Data showed that DML markedly improved neurobehavioral scores and reduced cerebral edema and infarction. In addition, DML significantly reduced malondialdehyde (MDA) content and elevated activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), in addition, marked decrease in levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-a (TNF-a). Data suggest that the protective effects of DML on CIRI may be related to processes involving antioxidation and anti-inflammation.]]> Mon 04 Feb 2019 11:46:05 AEDT ]]>